Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT2C Receptor Positive Allosteric Modulators with Enhanced Drug-Like Properties.

Eric A. Wold,Erik J. Garcia,Christopher Wild,Joanna Miszkiel,Claudia A. Soto,Jianping Chen,Konrad Pazdrak,Robert G. Fox,Noelle C. Anastasio,Kathryn A. Cunningham,Jia Zhou

Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT2C Receptor Positive Allosteric Modulators with Enhanced Drug-Like Properties.

2020

Eric A. Wold
Erik J. Garcia
Christopher Wild
Joanna Miszkiel
Claudia A. Soto
Jianping Chen
Konrad Pazdrak
Robert G. Fox
Noelle C. Anastasio
Kathryn A. Cunningham
Jia Zhou

Targeting the serotonin (5-HT) 5-HT2C receptor (5-HT2CR) allosteric site to potentiate endogenous 5-HT tone may provide novel therapeutics to alleviate the impact of costly, chronic diseases such a...

Keywords:

Endogeny
Biochemistry
5-HT2C receptor
Allosteric regulation
Chemistry
Serotonin
Carboxamide
4-Phenylpiperidine
Receptor
Drug

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