Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells

Michael Kharas and colleagues characterize the MSI2 protein interactomein leukemiacells and subsequently perform a functional screen identifying 24 genes required for leukemiain vivo. They focus on the RNA-binding proteinSYNCRIP, showing that it regulates Hoxa9 and other transcripts involved in a myeloid leukemiastem cell program.