Contribution of lncRNA CASC8, CASC11 and PVT1 genetic variants to the susceptibility of coronary heart disease.

ABSTRACT The purpose of this present study was to explore the relationship between lncRNA CASC8, CASC11 and PVT1 genetic variants and coronary heart disease (CHD) susceptibility among a Chinese Han population. Five single nucleotide polymorphism (SNPs) were genotyped by Agena MassARRAY platform among 464 CHD patients and 510 healthy controls. Binary logistic regression models by calculating odds ratios (ORs) with 95% confidence intervals (CI) were used to assess the association between selected SNPs and CHD risk. Multifactor dimensionality reduction (MDR) analysis was performed to analyze gene-gene interaction. PVT1 rs4410871 (OR = 0.77, p = 0.040) was associated with a reduced risk of CHD occurrence in the Chinese population. CASC11 rs9642880 (OR = 1.49, p = 0.021) was a risk factor for increased CHD susceptibility in subjects over 60 years old, and PVT1 rs4410871 was a protective factor for CHD susceptibility in males (OR = 0.67, p = 0.015) and smokers (OR = 0.62, p = 0.047). Complications (hypertension or diabetes) of CHD influenced the association between CASC8, CASC11 and PVT1 genetic polymorphisms and CHD predisposition. Moreover, CASC8, CASC11 and PVT1 polymorphisms were related to the number of pathological branches and Gensini score in CHD patients. The study displayed the contribution of CASC8, CASC11 and PVT1 genetic polymorphisms to CHD predisposition, and these variants could serve as potential biomarkers of CHD susceptibility. These findings contribute to enhancing the understanding of the role of lncRNA polymorphisms in CHD risk.