Response of biomarkers to treatment in mouse models of spinal muscular atrophy and response of SMA mice to later treatment

Response of biomarkers to treatment in mouse models of spinal muscular atrophyand response of SMA mice to later treatment A. Burghes*, W. Arnold , V. McGovern , S. Duque , J. Li , C. Iyer , K. Corlett , K. von Herrmann , P. Zaworski , K. Chen , S. Kolb , S. Paushkin , D. Kobayashi , S. Rutkove 3 1 Ohio State University, Molecular and Cellular Biochemistry, Columbus, USA; 2 Ohio State University, Neurology, Columbus, USA; 3 Harvard Medical School, Neurology, Boston, USA; 4 SMA Foundation, New York, USA; 5 PharmOptima, Portage, USA; 6 Cydan Development, Cambridge, USA