Means of evaluation and protection from doxorubicin-induced cardiotoxicity and hepatotoxicity in rats
2014
Objectives: This work is aimed on the study of
doxorubicin cardiotoxicityand hepatotoxicity in rats and the evaluation of protective effect of
trimetazidineadministrated concomitantly with
doxorubicinfor 3 days. Materials and Methods: Male Wistar rats used were subjected to different types of treatment (3 days); A: Control, B:
Doxorubicintreatment and C:
Trimetazidineand
doxorubicintreatment. After sacrifice, tissular distribution of
doxorubicin, cardiac
scintigraphy, histological examination of the myocardium, and evaluation of liver function were assessed. Results: Obtained results show that
doxorubicinhas a high affinity to tissues especially the heart. It causes hepatotoxicity and
cardiotoxicitymarked by a significant increase of aspartate aminotransaminase (AST) and alanine aminotransaminase (ALT) levels and drop of the left ventricular ejection fraction (EF LV ) by
scintigraphy. Histological examination showed general alteration of myocardium structure. Concomitant administration of
trimetazidineattenuates significantly the
cardiotoxicityand hepatotoxity induced by
doxorubicin. Conclusion: We have evaluated the protective effect of
trimetazidineon an animal model of
doxorubicin-induced
cardiotoxicityand hepatotoxicity. The evaluation of these effects were assessed by several means; tissular distribution of
doxorubicin, histological examination, assessment of liver function, and EF LV by
scintigraphythat characterizes the originality of this study.
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