IID572: A New Potentially Best-In-Class β-Lactamase Inhibitor
2019
Resistance in
Gram-negative bacteriato β-
lactamdrugs is mediated primarily by the expression of β-lactamases, and co-dosing of β-
lactamswith a β-lactamase inhibitor (BLI) is a clinically proven strategy to address resistance. New β-lactamases that are not impacted by existing BLIs are spreading and creating the need for development of novel broader spectrum BLIs. IID572 is a novel broad spectrum BLI of the diazabicyclooctane (DBO) class that is able to restore the
antibacterial activityof
piperacillinagainst
piperacillin/tazobactam-resistant clinical isolates. IID572 is differentiated from other DBOs by its broad inhibition of β-lactamases and the lack of intrinsic
antibacterial activity.
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