Role of p53 and Ki-67 in prognostication of carcinoma breast

Introduction: Tumor markers are used for the detection of risk, population screening, diagnosis, staging and prognosis. The present study was commenced out to study efficacy of p53 and Ki67 as Prognostic marker in breast carcinoma and to find correlation of ER, PR, HER2neu with p53 and Ki67 in confirmed cases of carcinoma Breast at a Tertiary Care Hospital. Materials and Methods: This was an observational study, undertaken on 50 confirmed cases of breast carcinoma diagnosed during September 2016 to July 2018. The histopathological grading of the breast carcinoma was done according to modified Bloom Richardson score. All the cases underwent immunohistochemistry for ER, PR, HER2neu, p53 and Ki 67 expression. The results were compiled and analyzed statistically. Result: In patient presenting with p53 overexpression,73.3% cases were Conclusion: The present study concludes that ER, PR reveals inverse relationship while p53 and Ki 67 showed direct relationship with tumor grade; and is also inversely correlated with ER, PR positivity. In young patients with carcinoma breast, the rates of mutation of Ki67 and p53 were higher, and higher frequency of metastasis, the patients who show increased Ki 67 expression have also got increased mitotic activity and less expression of ER, PR; thus carrying a poor prognosis and requires the treatment accordingly. Keywords: Carcinoma Breast, p53, Ki67.