The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells

Ajithkumar Vasanthakumar,Kazuyo Moro,Annie Xin,Yang Liao,Renee Gloury,Shimpei Kawamoto,Sidonia Fagarasan,Lisa A. Mielke,Shoukat Afshar-Sterle,Seth L. Masters,Susumu Nakae,Hirohisa Saito,John M. Wentworth,Peng-Peng Li,Wei Liao,Warren J. Leonard,Gordon K. Smyth,Wei Shi,Stephen L. Nutt,Shigeo Koyasu,Axel Kallies

The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells

2015

Obesity-associated inflammation is restrained by regulatory T cellspresent in visceral fat. Kallies and colleagues show interleukin 33and the transcription factors BATFand IRF4are necessary to maintain visceral adipose tissue Treg cells.

Keywords:

Inflammation
Immunology
Interleukin 33
Transcription factor
IRF4
Biology
Immunogenetics
BATF
Adipose tissue
Cellular differentiation
Interferon regulatory factors
Interleukin
Cell biology

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