Angiotensin II Type 1 Receptor Antagonism Attenuates Abnormalities in Dynamic Renal Blood Flow Autoregulation in Rats with Endotoxin-Induced Acute Kidney Injury.

Background: The aim was to examine the role of angiotensin II type 1 receptors in dynamic autoregulation of renal blood flow (RBF) in endotoxemia. Methods: Experiments were performed on anesthetized rats 16 h after intraperitoneal lipopolysaccharide (LPS) or vehicle administration. After baseline measurements, groups Sham-Saline, LPS-Saline and LPS-Candesartan received isotonic saline or candesartan (10 µg kg–1 i.v.). Data were collected during eight consecutive 20-min clearance periods (C1–8). Transfer function (TF) analysis in the frequency domain was used to examine dynamic autoregulation of RBF. Results: Endotoxemic rats showed an approximate 50% reduction in glomerular filtration rate (GFR) and RBF (p Conclusion: Candesartan ameliorates the adverse effect of endotoxin on the TGF component of dynamic autoregulation of RBF.