Effects of the cardioselective KATP channel blocker HMR 1098 on cardiac function in isolated perfused working rat hearts and in anesthetized rats during ischemia and reperfusion

It has been argued that activation of KATP channels in the sarcolemmal membrane of heart muscle cells during ischemiaprovides an endogenous cardioprotectivemechanism. In order to test whether the novel cardioselective KATP channel blockerHMR 1098 affects cardiac function during ischemia, experiments were performed in rat hearts during ischemiaand reperfusion.