Longterm remission of more than 5 years in a patient with progressive multifocal leucoencephalopathy and sarcoidosis

Progressive multifocal leukoencephalopathy (PML) represents sually a fatal demyelinating disorder that is caused by JC polyoma irus infection of oligodendrocytes. PML has been observed as a omplication in patients with lymphoproliferative disorders, in HIV nfected patients with low CD4 T cell counts and in patients underoing stem cell transplantation. Within the last few years PML has merged as a potential complication in patients with autoimmune isorders and in particular has been associated with the therapeuic use of potent immunosuppressive treatment regimen including onoclonal antibodies such as natalizumab for multiple sclerosis, falizumab for psoriasis, rituximab for lymphoma and SLE and more ecently for rheumatoid arthritis.