Biologic therapies for refractory juvenile dermatomyositis: five years of experience of the Childhood Arthritis and Rheumatology Research Alliance in North America

Background The prognosis of children with juvenile dermatomyositis(JDM) has improved remarkably since the 1960’s with the use of corticosteroid and immunosuppressive therapy. Yet there remain a minority of children who have refractory disease. Since 2003 the sporadic use of biologics ( genetically-engineeredproteins that usually are derived from human genes) for inflammatory myositishas been reported. In 2011–2016 we investigated our collective experience of biologics in JDM through the Childhood Arthritisand RheumatologyResearch Alliance (CARRA).