Synthesis of Novel 7-Substituted Pyrido[2′,3′:4,5]furo[3,2-d]pyrimidin-4-amines (VII) and Their N-Aryl Analogues (IX) and Evaluation of Their Inhibitory Activity Against Ser/Thr Kinases.

Among the compounds synthesized derivative (VIIb) shows the best inhibitory activity and appears to be specific to CLK1among the panel of the tested kinases.