del(17p) in myeloid malignancies

Identity Alias: 17p syndrome in myeloid malignancies Note: Recently, we and others reported in ANLL and MDS a strong correlation between 17p deletion (a clonal cytogenetic anomaly consisting of a deletion of the short arm of chromosome 17), and a particular form of morphological dysgranulopoiesis, we also found in such cases a strong correlation between 17p deletion and p53 mutation; these correlations suggest that ANLL and MDS with 17p deletion constitute a new morphologicalcytogenetic-molecular entity, the " 17p syndrome "