Emergence of the E484K Mutation in SARS-CoV-2 Lineage B.1.1.345 in Upstate New York.

A SARS-CoV-2 B.1.1.345 variant carrying the E484K mutation was detected in four patients with no apparent epidemiological association from a hospital network in upstate New York. Subsequent analysis identified an additional eleven B.1.1.345 variants from this region between December 2020 and February 2021.