Two cases of 8p trisomy in one sibship

Two cases of 8p trisomyin one sibship are presented. The father was a balanced carrier of a translocation rep (8;13) (p11; q34). Case 1 was a 2-year-old boy with multiple minor anomalies and severe mental retardation. Giemsa banding studies revealed that he was trisomic for the greater part of 8p (8p11 pter). When his mother became pregnant again, amniocentesiswas carried out in the 17th week of gestation. The fetus (Case 2) was shown to have the same 8p trisomyas Case 1. The pregnancy was terminated in the 22nd week. An autopsy revealed no major anomalies. Clinical features of cases with 8 and 8p trisomyare reviewed briefly.