Investigation on Ultrasonic Exposure Sequence by Luminol Sonochemiluminescence for Highly Effective Sonodynamic Treatment

Sonodynamic treatment (SDT) is a treatment modality for cancer, combining ultrasound, reactive oxygen species (ROS), and drug which enhances the generation of ROS. Although cancers can be noninvasively treated by SDT, it has a disadvantage of long treatment time. In this study, the effect of ultrasound sequences on the efficiency of ROS generation was investigated by using luminol sonochemiluminescence and high-speed photography of cavitation bubbles.