Serum Uric Acid Level and Cardiovascular Disease Development Risk in Stage 3-5 Chronic Kidney Disease Patients

Aim: The patients with chronic kidney disease (CKD) have higher risk of cardiovascular disease (CVD) than the general population and this risk increases in advanced CKD stages. The data about the association between CVD and uric acid level in stage 3-5 CKD patients are limited in the literature. The aim of this study is to investigate whether uric acid levels are associated with cardiovascular events and mortality in the CKD patients. Material and Methods: Patients who were followed up with the diagnosis of stage 3-5 CKD between June 2014 and December 2019 were evaluated retrospectively. A hundred stage 3-5 CKD cases above the age of eighteen were included in the study. The patients were divided into two groups according to average serum uric acid levels; <7 mg/dL and ≥7 mg/dL. Any confirmed diagnosis of stroke, myocardial infarction, coronary heart disease or heart failure was accepted positive for the history of CVD. Results: Cardiovascular event development was observed in 15 patients and mortality in 1 patient. CVD were seen in 10 (21.3%) patients in group 1 while 5 (9.4%) patients in group 2. Although the cardiovascular events were seen more in the group 1, this difference was not statistically significant (p=0.098). Conclusion: Although CVD is seen higher in the low uric acid (<7 mg/dL) group, no significant association was found between serum uric acid level and development of CVD in stage 3-5 CKD patients, in this study. Prospective studies with larger sample sizes may provide better evidence regarding possible relationship.