Skp2 targeting suppresses tumorigenesis by Arf-p53 -independent cellular senescence

Cellular senescence— an irreversible cell-cycle arrest — has been implicated in suppressing tumour formation or growth. A new cellular signalling pathway that drives senescencehas now been identified. This pathway does not involve most known mediators of senescence, and instead signals via the proteins Atf4, p27 and p21. Inactivating the proto- oncogene Skp2in the context of oncogenicsignalling can induce senescencethrough this new pathway, indicating that drugs that target Skp2might be useful in cancer treatment.