Identification of new schizophrenia susceptibility loci in an ethnically homogeneous, family-based, Arab-Israeli sample
2011
While the use of population-based samples is a common strategy in
genome-wide association studies(GWASs), family-based samples have considerable advantages, such as robustness against
population stratificationand false-positive associations, better quality control, and the possibility to check for both linkage and association. In a genome-wide linkage study of schizophrenia in Arab-Israeli families with multiple affected individuals, we previously reported significant evidence for a susceptibility locus at chromosome 6q23.2-q24.1 and suggestive evidence at chromosomes 10q22.3–26.3, 2q36.1–37.3 and 7p21.1–22.3. To identify schizophrenia susceptibility genes, we applied a family-based GWAS strategy in an enlarged, ethnically homogeneous, Arab-Israeli family sample. We performed genome-wide single nucleotide polymorphism (
SNP)
genotypingand single SNP
transmission disequilibrium testassociation analysis and found genome-wide significant association (
best valueof P=1.22×10−11) for 8 SNPs within or near h...
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