Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNFα Identified Using Scaffold Hopping and Structure-Based Drug Design Approaches.

Hai-Yun Xiao,Ning Li,Jingwu Duan,Bin Jiang,Zhonghui Lu,Khehyong Ngu,Joseph A. Tino,Lisa M. Kopcho,Hao Lu,Jing Chen,Andrew J. Tebben,Steven Sheriff,ChiehYing Y. Chang,Joseph Yanchunas,Deepa Calambur,Mian Gao,David J. Shuster,Vojkan Susulic,Jenny Xie,Victor R. Guarino,Dauh-Rurng Wu,Kurt R. Gregor,Christine B. Goldstine,John Hynes,John E. Macor,Luisa Salter–Cid,James R. Burke,Patrick J. Shaw,T. G. Murali Dhar

Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNFα Identified Using Scaffold Hopping and Structure-Based Drug Design Approaches.

2020

Scaffold hopping and structure-based drug design were employed to identify substituted 4-aminoquinolines and 4-aminonaphthyridines as potent, small molecule inhibitors of tumor necrosis factor alph...

Keywords:

Drug
Tumor necrosis factor alpha
structure based
scaffold hopping
Small molecule
In vivo
Biophysics
Chemistry

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