Boys with Asperger Syndrome Grow Up: Psychiatric and Neurodevelopmental Disorders 20 Years After Initial Diagnosis

We examined comorbidpsychiatric and neurodevelopmental disordersin fifty adult males (mean age 30 years) with Asperger syndrome(AS) diagnosed in childhood and followed up prospectively for almost two decades (13–26 years). Only three of the 50 men had never met criteria for an additional psychiatric/neurodevelopmental diagnosis and more than half had ongoing comorbidity(most commonly either ADHD or depression or both). Any psychiatric comorbidityincreased the risk of poorer outcome. The minority of the AS group who no longer met criteria for a full diagnosis of an autism spectrum disorderwere usually free of current psychiatric comorbidity. The high rate of psychiatric/neurodevelopmental comorbiditiesunderscores the need for a full psychiatric/neurodevelopmental assessment at follow-up of males with AS.