Renal Denervation Update From the International Sympathetic Nervous System Summit: JACC State-of-the-Art Review

Highlights •Sympathetic nervous system activation is a key contributor to elevated BP. •Catheter-based RDN reduces BP in both treated and drug naive patients. •Improved trial design, patient selection, and optimized procedural approaches contributed to these positive findings. •Future research will focus on reducing the variability of the BP response and indications beyond hypertension.