Proliferating cell nuclear antigen immunohistochemistry in epithelial-myoepithelial carcinoma of the salivary glands
1993
Myoepithelial-type cells are largely predominant in the composition of aggressive recurrent
epithelial-myoepithelial carcinoma, suggesting that such tumor
cell lineageconstitutes a highly proliferating neoplastic population. Thirteen cases of
epithelial-myoepithelial carcinoma, seven of the solid type and six of the tubular-
cribriformtype, were
immunostainedwith the anti-
proliferating cell nuclear antigenPC10 antibody to evaluate the proliferative activity of the two tumor cell components. Positively stained nuclei were only observed in the
myoepithelial cells. Only one of the 13 cases, of tubular architectural type, had a few but unequivocally positive ductlike cells. The percentage of cycling
clear cellsvaried between 0.2% and 45.7%
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