Multistimuli-responsive magnetic assemblies

Abstract Stimuli-responsive nanomaterial offered an alternative to design drugdelivery system in spatial-, temporal-, and dosage-controlled fashions. There is increasing trend to design and synthesize polymers which mimic in part the stimuli-responsive character of the biopolymers, respond to external stimuli on small change in the surrounding environment of our body. Additionally, external stimuli (light, magnetic field, and ultrasound) could develop into theranostic applications for personalized medicineuse because of their unique characteristics. Currently, intense efforts are underway to design, characterize, and synthesize multiresponsive polymeric nanocarriers, which lead to high spatiotemporal control over therapeutic delivery and extreme dose control. In this direction, assembling of iron oxide nanoparticleswhich offer superparamagnetic property and their intrinsic magnetic property for hyperthermal therapy and stimuli-responsive polymers is one of an alternative strategy to design such multiresponsive nanocarriers. In view of the significance of these applications, it is vital to understand the correlation between structure and property application since this would lead to develop as well as rationally design novel stimuli-responsive polymeric materials for future biomedical applications. Incorporation of stimuli-sensitive function in the polymers to modulate biomedical applications will be a very interesting area of research in the future.