METHODS AND MARKERS FOR ASSESSING CANCER PROGRESSION

The present disclosure relates to methods and markers for assessing cancer progression. In certain embodiments, the present disclosure provides a method of assessing progression of a cancer disease associated with increased or undesired receptor tyrosine kinase activity, the method comprising assessing endosomal recycling of the receptor tyrosine kinase mediated by phosphorylated PKCΔ associated with the cancer disease, wherein increased endosomal recycling of the receptor tyrosine kinase is indicative of progression of the cancer disease from a less progressed stage to a more progressed stage.