Isolation of maltol derivatives from Stellera chamaejasme and the anti-atopic properties of maltol on skin lesions in DNCB-stimulated mice

The aim of this study was to isolate maltolderivatives from S. chamaejasme and to investigate the anti-atopic dermatitis (anti-AD) effect of maltolin a 2,4-dinitrochlorobenzene(DNCB)-sensitized mouse model of AD. A novel compound, maltol3-O-(4′-O-cis-p-coumaroyl)-β-D-glucoside (named isosoyamaloside I), and two known maltolderivatives ( maltoland soyamaloside I) were isolated from S. chamaejasme using chromatographic methods. Dermal application of maltolto DNCB-sensitized AD mice reduced erythema, pruritus, and lichenificationscores. Histopathological examinations revealed significant decline in mast cell infiltration in maltol-treated AD mice. In addition, maltolaccelerated skin barrier recovery by reducing TEWL and skin pH and increasing skin hydration. Maltolwas also found to suppress atopy-induced IL-4 and IgE elevations in serum, which are known to be essential for the development of atopy. The results of this study show that maltolis a potential therapeutic candidate for the treatment of AD-related skin diseases.