Sequential V˙a/Q˙ distributions in the normal rabbit by micropore membrane inlet mass spectrometry
2000
We developed micropore membrane inlet mass spectrometer (MMIMS) probes to rapidly measure
inert-gas
partial pressuresin small blood samples. The mass spectrometer output was linearly related to
inert-gas
partial pressure( r 2 of 0.996–1.000) and was nearly independent of large variations in
inert-gas solubility in liquid samples. We infused six
inertgases into five
pentobarbital-anesthetized New Zealand rabbits and used the MMIMS system to measure
inert-gas
partial pressuresin systemic and pulmonary arterial blood and in mixed expired gas samples. The retention and excretion data were transformed into distributions of ventilation-to-perfusion ratios (V˙a/Q˙) with the use of linear regression techniques. Distributions ofV˙a/Q˙ were
unimodaland broad, consistent with prior reports in the normal rabbit. Total blood sample volume for eachV˙a/Q˙ distribution was 4 ml, and analysis time was 8 min. MMIMS provides a convenient method to perform the
multiple inert-gas elimination techniquerapidly and with small blood sample volumes.
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