Growth Failure Prevalence in Neonates with Gastroschisis: A Statewide Cohort Study.

OBJECTIVES To perform a multicenter study to assess growth failure in hospitalized infants with gastroschisis. STUDY DESIGN This study included neonates with gastroschisis within sites in the University of California Fetal Consortium (UCFC). The study's primary outcome was growth failure at hospital discharge, defined as a weight or length z-score decrease > 0.8 from birth. Regression analysis was performed to assess changes in z-scores over time. RESULTS Among 125 infants with gastroschisis, the median gestational age was 37 weeks (IQR 35-37). Length of stay was 32 days (23-60); 55% developed weight or length growth failure at discharge (28% had weight growth failure, 42% had length growth failure, and 15% had both weight and length growth failure). Weight and length z-scores at 14 d, 30 d, and discharge were less than birth (p<0.01 for all). Weight and length z-scores declined from birth to 30 days (-0.10 and -0.11 z-score units/week, respectively, P < .001). Length growth failure at discharge was associated with weight and length z-score changes over time (p <0.05 for both). Lower gestational age was associated with weight growth failure (OR=0.70 for each gestational age week, 95% CI 0.55-0.89, p=0.004). CONCLUSION Growth failure, in particular linear growth failure, is common in infants with gastroschisis These data suggest the need to improve nutritional management in these infants.