Maternal anemia type during pregnancy is associated with anemia risk among offspring during infancy
2019
We evaluated the association between etiology of
maternal
anemiaand iron status throughout infancy. Samples from a study designed to examine
Praziquanteltreatment during pregnancy were used (n = 359). All women were infected with
schistosomiasisand randomized to
Praziquantelor placebo at 16 ± 2 weeks’ gestation. Hemoglobin, serum ferritin (SF),
soluble transferrin receptor(sTfR),
hepcidin, C-reactive protein, and interleukin-6 were measured in
maternaland infant blood. The relationship between both
maternal
Praziquanteltreatment and etiology of
anemiaand infant iron status was evaluated.
Maternal
iron-deficiency anemiawas associated with increased risk of infant
anemiaat 6 months of age. Infants of mothers with the lowest levels of circulating
hepcidinduring gestation, likely a marker for iron deficiency, had higher sTfR:SF levels and lower hemoglobin levels, particularly at 12 months of age.
Maternalnon-
iron-deficiency anemia(NIDA) did not impact infant
anemiarisk or iron status.
Maternaltreatment for
schistosomiasishad no effect on infant hematologic status.
Maternal
iron deficiency anemiawas associated with an increased risk for
anemiaor iron deficiency during late infancy. We did not observe an association between
maternalNIDA and increased risk for iron deficiency during infancy.
Keywords:
-
Correction
-
Source
-
Cite
-
Save
35
References
8
Citations
NaN
KQI