Pseudosaccharin amines as potent and selective KV1.5 blockers
2015
Abstract Phenethyl aminoheterocycles like compound 1 were known to be potent I Kur blockers although they lacked potency in vivo. Modification of the heterocycle led to the design and synthesis of pseudosaccharin amines. Compounds such as 14 , 17d and 21c were found to be potent K V 1.5 blockers and selective over other cardiac
ion channels. These compounds had potent
pharmacodynamicactivity, however, they also showed off-target activities such as hemodynamic effects.
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