Selektive Cyclooxygenase-II-Hemmer bei Patienten mit pseudoallergischen Reaktionen auf nichtsteroidale Antiphlogistika

Pseudoallergic reactions to non-steroidal anti-inflammatorydrugs (NSAID) are frequently occurring side-effects during the treatment of chronic pain conditions and non-infectious inflammation. The incidence is estimated to be 2%. In severe cases anaphylactoid reactionsmay develop. Patients suffering from this disease are therefore frequently transferred to allergologic units for diagnosis. Here, we review current insights into the pathomechanisms and treatment modalities of NSAID-intolerance. Especially, we address the use of new anti-inflammatorydrugs with selective inhibition of the Cyclooxigenase II, since these drugs may have a lower riskof pseudo-allergic reactions in patients with NSAID-intolerance.