Defective anti-polysaccharide response and splenic marginal zone disorganization in ALPS patients

Bénédicte Neven,Julie Bruneau,Marie-Claude Stolzenberg,Isabelle Meyts,Aude Magerus-Chatinet,Leen Moens,Nina Lanzarotti,Sandra K. Weller,Denise Amiranoff,Benoit Florkin,Brigitte Bader-Meunier,Guy Leverger,Alice Ferster,Christophe Chantrain,Stéphane Blanche,Capucine Picard,Thierry Molina,Nicole Brousse,Anne Durandy,Marta Rizzi,Xavier Bossuyt,Alain Fischer,Frédéric Rieux-Laucat

Defective anti-polysaccharide response and splenic marginal zone disorganization in ALPS patients

2014

Autoimmune lymphoproliferative syndrome(ALPS) caused by impaired FAS-mediated apoptosis of lymphocytes is characterized by lymphoproliferation, autoimmunity, but also an increased risk of invasive bacterial infection, notablyfollowing splenectomy. We surveyed a cohort of 100 ALPS patients (

Keywords:

Cohort
Autoimmune lymphoproliferative syndrome
Streptococcus pneumoniae
Splenic Marginal Zone
Apoptosis
Autoimmunity
Immunology
Splenectomy
Pathology
Medicine
Diabetes mellitus
Polysaccharide

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