Abstract B2-13: AU-rich expression in invasive ductal breast cancer: A systems biology approach in post-transcriptional regulation

AU-Rich element(ARE)-dependent post-transcriptional regulationmechanisms are increasingly emerging as key regulators that are influencing our perception of aberrant gene expression in cancer. AREs are instability determinant sequences located in the 39 UTR of mRNAs and are fundamental to the maintenance of transient expression of gene products that regulate various cellular functions such as cell proliferation, apoptosis, inflammation and immunity. Here we used a systems biologyapproach to examine the patterns of ARE-containing gene expression that is perturbed in invasive ductal breast cancer (IDBC). Based on IDBC mRNA expression profiles obtained from The Cancer Genome Atlas (TCGA) database, we intersected 2396 over-expressed genes with the AU-rich elementdatabase (ARED) and found that 414 comprise IDBC upregulated ARE-containing genes. Functional classification using the gene ontology tool, DAVID, showed the highest enrichment of ARE-genes in IDBC in chromosome segregation(5-fold, p Citation Format: Norah A. Alsouhibani, Edward Hitti, Tala Bakheet, Khalid SA Khabar. AU-rich expression in invasive ductal breast cancer: A systems biologyapproach in post-transcriptional regulation. [abstract]. In: Proceedings of the AACR Special Conference on Computational and Systems Biologyof Cancer; Feb 8-11 2015; San Francisco, CA. Philadelphia (PA): AACR; Cancer Res 2015;75(22 Suppl 2):Abstract nr B2-13.