Clinicopathologic features and treatment outcome of mature T-cell and natural killer-cell lymphomas diagnosed according to the World Health Organization classification scheme: a single center experience of 10 years
2005
Background: Data on mature T-cell and natural killer (NK)-cell
lymphomasdiagnosed with the World Health Organization (WHO) classification scheme are scarce. They are regarded to be more common in Asian populations. Methods: Consecutive T-cell and NK-cell
lymphomasclassified according to the WHO scheme within 10 years in a Chinese population were reviewed. Results: There were 148 cases, constituting 16.6% (T-cell, n = 90, 10.1%, NK-cell, n = 58, 6.5%) of all non-Hodgkin
lymphomasin this period. There was a male predominance (male:female = 2.5), young age at diagnosis (median age 50 years, range 8 ‐ 86) and frequent extranodal presentation. Commonest
T-cell lymphomasincluded
anaplastic large cell lymphoma(ALCL, n = 25, median age 35 years, nodal 60%, stage I/II 60%),
peripheral T-cell lymphoma, unspecified (PTCL, n = 24, median age 54 years, nodal 42%, stage I/II 42%), and
angioimmunoblastic T-cell lymphoma(AILT, n = 19, median age 67 years, nodal 95%, stage I/II 26%). Overall frequencies of
T-cell lymphomaswere comparable to Western patients. AILT, PTCL and ALCL were aggressive with a poor outcome. NK-cell
lymphomaswere predominantly extranodal (96%) and aggressive, with a frequency much higher than Western patients. Conclusions: The apparent high prevalence of T-cell and NK-cell
lymphomasin the Chinese was
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