Inflammatory demyelination induces glia alterations and ganglion cell loss in the retina of an experimental autoimmune encephalomyelitis model

Background Multiple sclerosis (MS) is often accompanied by optic nerveinflammation. And some patients experiencepermanent vision loss. We examined if the grade of optic nerveinfiltration and demyelination affects the severity of clinical signs in an experimental autoimmune encephalomyelitis(EAE) model. The loss of retinal ganglion cells(RGC) and alterations in glia activity were also investigated.