Amerindian-specific regions under positive selection harbour new lipid variants in Latinos.

Dyslipidemia and obesity have a high prevalence in populations with Amerindian backgrounds, such as Mexican–Americans. Here, the authors design an approach to identify Amerindian risk genes in Mexicans and identify five genomic loci, which include RORA and SIK3 that may contribute to the risk of dyslipidemia and obesity in Amerindian populations.