Novel Screening Method Identifies PI3Kα, mTOR, and IGF1R as Key Kinases Regulating Cardiomyocyte Survival

Manar Elmadani,Suleiman A. Khan,Olli Tenhunen,Johanna Magga,Tero Aittokallio,Krister Wennerberg,Risto Kerkelä

Novel Screening Method Identifies PI3Kα, mTOR, and IGF1R as Key Kinases Regulating Cardiomyocyte Survival

2019

Manar Elmadani
Suleiman A. Khan
Olli Tenhunen
Johanna Magga
Tero Aittokallio
Krister Wennerberg
Risto Kerkelä

Background Small molecule kinase inhibitors (KIs) are a class of agents currently used for treatment of various cancers. Unfortunately, treatment of cancer patients with some of the KIs is associat...

Keywords:

Small molecule
PI3K/AKT/mTOR pathway
Cardiology
Cardiotoxicity
Internal medicine
Kinase
Diabetes mellitus
Cancer research
Medicine
Insulin-like growth factor 1 receptor
Cancer
Programmed cell death
Apoptosis

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