Application of critical care scores in severely burned patients.

Early detection of sepsis is of crucial importance in patients with severe burn injuries. However, according to the S1-guideline , based on SIRS criteria, the early diagnosis of sepsis in severely burned patients is difficult. The value of the new definition of sepsis based on sequential organ failure assessment (SOFA) according to S3-guidelines for patients with severe burn injuries is not described in detail in literature.We analyzed retrospectively all data during the period 2014-2018 from the electronic patient information system. Using Receiver operating characteristic (ROC) curve the area under the curve (AUC) was calculated for diagnostic value of procalcitonin (PCT), SIRS and SOFA score according to the burned total body surface area (TBSA). 651 patients with burn injuries were admitted to our burn unit, 315 of them had burn injuries affecting more than 10% body surface area with partial to full thickness burn (grade 2-4) . In this group, 59 patients showed one or more septic events in the course of the intensive care treatment, defined by positive blood stream infection. Both S1- and S3- guidelines were inappropriate to diagnose sepsis in patients with severe burn injuries. Due to pathophysiological changes of the body function in severely burned patients, that show features of both SIRS and pathological SOFA scores (> 2 points) at the outset of burn injury, the diagnosis of sepsis associated with burns is intricate in this patient group. Assessing data for potential hallmarks of sepsis in burn patients we found PCT to show significant correlation with sepsis.