Pharmacokinetics of gentamicin and vancomycin during continuous venovenous hemofiltration in critically ill septic patients with acute kidney injury

Acute kidney injury (AKI) is a common complication of critical illness and sepsis [1]. Dosing of antibacterial agents in septic patients is complicated by altered pharmacokinetics due to both acute renal failure and critical illness [2]. Current dosing regimens for administration of gentamicin and vancomycin to septic patients with AKI on continuous venovenous hemofiltration (CVVH) at a filtration rate of 45 ml/kg/hour are missing.