Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase

Leah S. Torrie,David A. Robinson,Michael G. Thomas,Judith V. Hobrath,Sharon M. Shepherd,John Post,Eun Jung Ko,Rafael Ferreira,Claire J. MacKenzie,Karolina Wrobel,Darren P. Edwards,Ian H. Gilbert,David W. Gray,Alan H. Fairlamb,Manu De Rycker

Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase

2020

Leah S. Torrie
David A. Robinson
Michael G. Thomas
Judith V. Hobrath
Sharon M. Shepherd
John Post
Eun Jung Ko
Rafael Ferreira
Claire J. MacKenzie
Karolina Wrobel
Darren P. Edwards
Ian H. Gilbert
David W. Gray
Alan H. Fairlamb
Manu De Rycker

Methionyl-tRNA synthetase (MetRS) is a chemically validated drug target in the kinetoplastid parasites Trypanosoma brucei and Leishmania donovani. To date, all kinetoplastid MetRS inhibitors descri...

Keywords:

Leishmania donovani
Methionyl-tRNA synthetase
drug target
Trypanosoma brucei
Allosteric regulation
Chemistry
Biochemistry
Drug discovery
Trypanosoma cruzi
Leishmania
Binding site
Enzyme
Homology modeling

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