Fibroid vascularisation assessed with three‐dimensional power Doppler ultrasound is a predictor for uterine fibroid growth: a prospective cohort study

Objective To analyse fibroid vascularisation measured with 3D Power Doppler in relation to absolute fibroid volume change during 12 months follow up and in relation to fibroid growth rate per year Design A prospective cohort study was performed between March 2012 and March 2014. Setting Outpatient clinic of the VU medical centre, Amsterdam. Population or Sample All premenopausal women diagnosed with a maximum of 2 fibroids with expectative management were consecutively included. Methods 3D ultrasound including Power Doppler was performed at baseline, 3, 6 and 12 months. Volume and vascular parameters were calculated using VOCAL software. Main Outcome Measures The relationship between vascular index (VI) at baseline and fibroid volume over time was analysed using linear mixed model analyses for repeated measurements. Secondly, the relationship between VI at baseline and fibroid growth rate per year was calculated using linear regression analyses. Analyses were adjusted for possible confounders. Results 66 women (mean age 42 years) completed 12 months follow up without treatment. Baseline fibroid vascularisation (VI) measured with 3D Power Doppler is correlated with fibroid volume at 12 months (p = 0.02). An increase of 1% in VI at baseline was associated with a 7.00 cm3 larger fibroid volume at 12 months. Furthermore, vascularisation was also associated with fibroid growth rate per year (p=0.04). Conclusion In women with uterine fibroids without therapy, baseline vascularisation (VI) measured with 3D Power Doppler is correlated with absolute fibroid volume change at 12 months and with fibroid growth rate per year. This article is protected by copyright. All rights reserved.