The role of macrophages in skin homeostasis
2017
The skin and its appendages comprise the largest and fastest growing organ in the body. It performs multiple tasks and maintains
homeostaticcontrol, including the regulation of body temperature and protection from desiccation and from pathogen invasion. The skin can perform its functions with the assistance of different immune cell populations. Monocyte-derived cells are imperative for the completion of these tasks. The comprehensive role of macrophages and
Langerhans cellsin establishing and maintaining skin homeostasis remains incompletely defined. However, over the past decade, innovations in mouse genetics have allowed for advancements in the field. In this review, we explore different
homeostaticroles of macrophages and
Langerhans cells, including wound repair, follicle regeneration,
salt balance, and cancer regression and progression in the skin. The understanding of the precise functions of myeloid-derived cells in the skin under basal conditions can help develop specific therapies that aid in skin and
hair follicleregeneration and cutaneous
cancer prevention.
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