V1-receptor mediated GSH efflux by vasopressin from rat hepatocytes

Abstract Vasopression increases sinusoidal effluxof GSH in the perfused rat liver. The mechanism of this effect was studied in the perfused rat liver and in isolated rat hepatocytes. Vasopressinstimulated GSH effluxin both systems and a V1-receptor antagonist (OPC-21268) significantly inhibited the effect of vasopressinsuggesting that vasopressinstimulates GSH effluxfrom rat hepatocytesvia V1-receptor.