The role of Pax2 in regulation of kidney development and kidney disease

Paired box2(Pax2) gene plays a crucial role in kidney development and is expressed in the nephric duct,mesenchyme of pronephrons,mesonephrons,and metanephrons with special spatial and temporal characteristic.Research in animals indicate that Pax2 can interact with many important transcription factors such as Gdnf,Ret,SHH,Wnt4,and Fgf to organize the nephric linage specification,pro/mesonephric tubule formation and descent,emergence of the ureteric bud,branching morphogenesis,and nephron induction.Pax2 is associated with various congenital renal and ureter malformations,and the mutation is easist to detected in Renal-coloboma syndrome.In renal cell carcinoma,Wilms tumor and many acquired kidney diseases Pax2 is expressed abnormally,whose diagnose and therapy value will be the focus of further research.This paper reviews the molecular structure,expression and regulation of Pax2 in kidney development and diseases.