Live birth rates remain stable in modified natural IVF despite low AMH: analysis of 638 cycles

Abstract Research question Do live birthrates (LBR) following modified natural IVF (mnIVF) differ according to serum AMH level? DesignRetrospective cohort study including 638 women aged ≤ 39 years starting their first mnIVF cycle at a university-affiliated private IVF center. Patients were divided into three groups, by level of AMH: ≤ 0.5 ng/ml (25th percentile), 0.51-2.03 ng/ml (25-75th, reference), and 2.04-6.56 ng/ml (75th). Analyses were stratified by AMH percentileand patients' ages ( Results LBR per started cycle were comparable across AMH percentiles(11.6%, 12.4% and 17% for the 25th, 25th-75 th , and 75th percentile, respectively; P =0.285). No statistically significant difference was found between the three AMH groups concerning the cancellation, successful egg retrieval, embryo transfer, or biochemical and clinical pregnancy rates. Logistic regression analysis did not identify AMH percentileas a significant predictor of live birth. Compared to the reference group, the odds ratios (OR [95%CI]) for live birthin the th AMH percentileand >75 th AMH percentilegroups were 0.97 [0.54-1.76] ( P =0.974) and 1.41 [0.82-2.41] ( P =0.209), respectively). The results were the same regardless of age group ( Conclusions Serum AMH cannot be used to predict mnIVF outcomes. Patients in lower/upper AMH percentilesreport pregnancy and LBR comparable to patients with normal AMH.