PI3Kδ Regulates the Magnitude of CD8 + T Cell Responses after Challenge with Listeria monocytogenes
2015
PI3Ks regulate diverse immune cell functions by transmitting intracellular signals from Ag, costimulatory receptors, and
cytokine receptorsto control cell division, differentiation, survival, and migration. In this study, we report the effect of inhibiting the
p110δsubunit of PI3Kδ on
CD8+ T cell responses to infection with the intracellular bacteria
Listeria monocytogenes. A strong dependency on PI3Kδ for IFN-γ production by
CD8+ T cells in vitro was not recapitulated after
Listeria infectionin vivo. Inactivation of PI3Kδ resulted in enhanced bacterial elimination by the
innate immune system. However, the magnitudes of the primary and secondary
CD8+ T cell responses were reduced. Moreover, PI3Kδ activity was required for
CD8+ T cells to provide help to other responding
CD8+ cells. These findings identify PI3Kδ as a key regulator of
CD8+ T cell responses that integrates extrinsic cues, including those from other responding cells, to determine the
collective behaviorof
CD8+ T cell populations responding to infection.
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