Poly(lactic acid)/poly(lactic-co-glycolic acid)-based microparticles: an overview
2019
Background Poly(
glycolic acid), poly(lactic acid) and poly(lactic-co-
glycolic acid) were approved by the United States Food and Drug Administration (FDA) in the 1970s as materials for the manufacturing of bioresorbable
surgical sutures, but soon became the reference materials for the preparation of sustained release formulations, especially injectable microparticles. Since the 1986 approval of Decapeptyl® SR, the first product based on
PLGAmicrospheres, more than 15 such products have been approved for clinical use.
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