Comprehensive analysis of epigenetically regulated genes in anergic T cells
2017
Abstract T cell anergy is one of the important mechanisms for
immune tolerance. The results of many studies investigating the mechanism for T cell anergy
inductionhave revealed that the expression of several genes was up-regulated in anergic T cells. It has also been demonstrated that the molecules encoded on those genes played a critical role in anergy
induction. However, the mechanism for their up-regulation has not previously been clarified. We examined in this study the changes in gene expression and
DNA methylationstatus caused by anergy
induction. Our results demonstrate that the expression of many genes was changed by anergy
induction, and that the
DNA methylationstatus of some of these genes was also changed. We show here by a GO analysis that the extent of the change in methylation status caused by anergy
inductionwas distinct between the groups of genes that were categorized.
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