Population Pharmacokinetic Modelling for Estimation of Remifentanil Metabolic-Ratio Using Non-steady-State Concentrations under Rapidly Adaptive Dosing

Purpose To predict steady-statemetabolite-to-drug concentration ratio(metabolic ratio) for analgesic drug remifentanil, using sparse non- steady-statedata from patients with normal or impaired renal functionduring individualised, highly variable and rapidly adaptive intravenous infusion.